A Concise Route to α′??Methoxy?螃摸?pyrones and Verticipyrone Based Upon the Desymmetrization of α, α′??Dimethoxy?螃摸?pyrone

…, C Prandi, F d'Herouville, J Maddaluno

Index: De Paolis, Michael; Rosso, Helena; Henrot, Matthias; Prandi, Cristina; Herouville, Florent D; Maddaluno, Jacques Chemistry - A European Journal, 2010 , vol. 16, # 37 p. 11229 - 11232

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Citation Number: 7

Abstract

Bacterial and parasitic diseases are two of the leading causes of death worldwide, with 175000 deaths attributed to hospital-acquired infections each year in Europe alone, stressing the need for innovative antibiotic research.[1, 2] Unsaturated pyrone polyketides constitute a broad family of molecules produced by various marine microorganisms from the Actinomycete family that, in some cases, exhibit interesting antifungal, antibiotic, or ...