Direct ortho Iodination of β??and γ??Aryl Alkylamine Derivatives

…, JM Álvarez??Gutiérrez, A Ballesteros…

Index: Barluenga, Jose; Alvarez-Gutierrez, Julia M.; Ballesteros, Alfredo; Gonzalez, Jose M. Angewandte Chemie - International Edition, 2007 , vol. 46, # 8 p. 1281 - 1283

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Citation Number: 31

Abstract

Selective CÀH functionalization reactions allow the rapid modification of available molecular scaffolds. Organometallic and electrophilic processes serve as synthetic tools to this end. Selective electrophilic aromatic substitution at the ortho position remains elusive in the case of monosubstituted arenes. Therefore, ortho-substituted derivatives are prepared typically by indirect strategies. Arynes,[1] or the orthometalated species obtained upon the treatment ...