Abstract The chemical behavior of latrunculins A (1) and B (2)(Lat A and B) under a variety of reaction conditions is described. The combination of the macrolide, the THP-lactol, and the 2- thiazolidinone rings was found to result in interesting unpredicted chemical transformations. The structures of two new Lats, 6, 7-epoxy-Lat A (3) and Lat M (4) isolated from Latrunculia magnifica are discussed.
![methyl (2Z,6Z,8S)-10-[(2S,6R)-6-hydroxy-6-[(4R)-2-oxo-1,3-thiazolidin-4-yl]oxan-2-yl]-3,8-dimethyldeca-2,6-dienoate Structure](https://image.chemsrc.com/caspic/346/122876-49-7.png)
