e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Reaction of 2-Methoxy-3 H-azepine with NBS: Efficient Synthesis of 2-Substituted 2 H-Azepines
CEJ Cordonier, K Satake, M Atarashi…
Index: Satake, Kyosuke; Okuda, Ryoichi; Hashimoto, Michiaki; Fujiwara, Yasushi; Watadani, Izumi; et al. Journal of the Chemical Society, Chemical Communications, 1991 , # 17 p. 1154 - 1156
The reaction of 2-methoxy-3 H-azepines, in the presence or absence of a nucleophile, with N-bromosuccinimide (NBS) gave a regioselective 1, 4-adduct from which the corresponding 2 H-azepine derivatives were formed via base-promoted hydrogen bromide elimination,
[Kubota, Yasuhiro; Satake, Kyosuke; Ikui, Ryusuke; Okamoto, Hideki; Kimura, Masaru Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 4 p. 805 - 811]
[Satake, Kyosuke; Saitoh, Hidekazu; Kimura, Masaru; Morosawa, Shiro Journal of the Chemical Society, Chemical Communications, 1988 , # 16 p. 1121 - 1123]
