Tetrahedron letters

Preparation of 2-trifluoromethylvitamin K analogs

T Taguchi, Y Suda, A Hosoda, Y Kobayashi

Index: Taguchi, Takeo; Suda, Yoshimitsu; Hosoda, Akihiko; Kobayashi, Yoshiro Tetrahedron Letters, 1988 , vol. 29, # 45 p. 5765 - 5766

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Citation Number: 3

Abstract

Presently available data on vitamin K-dependent and 02-dependent carboxylation of glutamyl (Glu) residue to yield Y-carboxyglutamyl (Gla) residue in protein, prothrombin and clotting factors, indicates the vitamin K-dependent de2rotonation at the y-position of the Glu residue in a reaction to possibly occur in conjunction with the formation of vitamin K-2, 3- epoxide. 1) However, it is still unclear how to couple these reactions and whether ...