Trifluoromethylated compounds are finding widespread application in pharmaceuticals, agrochemicals, and liquid crystals due to their extreme properties. 1 Among various methodologies available for the preparation of trifluoromethylated compounds, the nucleophilic trifluoromethylation reaction using Ruppert's reagent ((trifluormethyl)trimethylsilane, Me 3 SiCF 3 ) is the most direct method for introducing a CF 3 unit into synthetically useful carbonyl compounds and ...
