Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin. gamma. 1: synthesis of 2-ketobicyclo [7.3. 1.] enediyne and 13- …

P Magnus, P Carter, J Elliott, R Lewis…

Index: Magnus; Carter; Elliott; Lewis; Harling; Pitterna; Bauta; Fortt Journal of the American Chemical Society, 1992 , vol. 114, # 7 p. 2544 - 2559

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Citation Number: 78

Abstract

Abstract: A general strategy for the construction of the bicyclo [7.3. lltridecenediyne core structure of the antitumor antibiotics esperamicin and calicheamicin can be realized provided the 10, ll-acetylenic bond is complexed as its derived g2 Co,(CO), adduct. The 10, l l-g2-2-ketobicyclo [7.3. 1] enediyne dicobalt hexacarbonyl adduct 38 was synthesized using qz dicobalt hexacarbonyl propargyl cation alkylation to form the crucial 10-membered ring. ...