Solid phase synthesis of a somatostatin amide analogue using acid labile t-Bumeoc protection and an acid labile anchor group

…, C Tzougraki, E Jungfleisch-Turgut

Index: Voelter, Wolfgang; Breipohl, Gerhard; Tzougraki, Chryssa; Jungfleisch-Turgut, Eveline Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 8 p. 1707 - 1718

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Abstract

Abstract The solid phase synthesis of an amidated somatostatin analogue based on the principle of differentiated acidolysis is described. The acid labile and smoothly cleavable t- Bumeoc moiety (1% TFA/DCM) is used for temporary N α-protection of D-and L-amino acids and [4-[[[9H-fluoren-9-yl-methoxycarbonyl] amino](4-methoxyphenyl) methyl]-2- methylphenoxy] acetic acid, attached to an aminomethylated polystyrene resin is used as ...