e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Lithium bromide-triethylamine induced cycloaddition of N-alkylidene 2-amino esters and amides to electron-deficient olefins with high regio-and stereoselectivity
This suggested the use of a weaker base which is basic enough to deprotonate la but does not initiate the undesired polymerization. A combination of a metal halide and a tertiary amine was tried since this combination has been effectively employed in the olefination with base-labile 2-oxoalkylphosphonates or 2-phosphoryl esters-l'To our delight, the treatment of la with lithium bromide and triethylamine in dry THF at room temperature generated the ...
