Enzymatic phosphorylation of the antiherpetic agent 9-[(2, 3-dihydroxy-1-propoxy) methyl] guanine

…, J Germershausen, R Bostedor, B Arison…

Index: Karkas; Ashton; Canning; Liou; Germershausen; Bostedor; Arison; Field; Tolman Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 842 - 848

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Citation Number: 23

Abstract

JD Karkas,* WT Ashton, L. F. Canning, R. Liou, J. Germershausen, R. Bostedor, B. Arison, AK Field, and RL Tolman Merck Sharp and Dohm. Research Laboratories, Rahway, New Jersey 07065, and West Point, Pennsylvania 19486. Received July 24, 1985 ... The antiherpetic agent 9- [ (2,3-dihydroxy-l-propoxy)methyl]guanine (iNDG) is phosphorylated by HSVl thymidine kinase, and its phosphorylated products inhibit DNA polymerase activity. iNDG exists in ...