New antitumor agents containing the anthracene nucleus

TP Wunz, RT Dorr, DS Alberts, CL Tunget…

Index: Wunz; Dorr; Alberts; Tunget; Einspahr; Milton; Remers Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1313 - 1321

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Citation Number: 45

Abstract

A final group of analogues was prepared from dialdehyde 27 by reductive amination, with sodium cyanoborohydride as the reducing agent. This method avoids a potential side reaction, since 33 is reactive enough to form ethers from alcohols in the presence of basic amines. Analogues 23-26 in Table I were prepared in this way. They have one basic nitrogen close in to the anthracene nucleus, but only a hydroxyl group (capable of ...