The first selective antagonist for a GABA C receptor

…, RM Woodward, R Miledi, LE Overman

Index: Murata, Yoshinori; Woodward, Richard M.; Miledi, Ricardo; Overman, Larry E. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 17 p. 2073 - 2076

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Citation Number: 94

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... (1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-1-ol, is the first γ-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABA C receptors. ... (1,2,5,6-Tetrahydropyridine-4-yl) ...