Abstract A series of analogues of N, N-di-n-propyldopamine (DPDA) in which the 3-hydroxyl group was replaced by bioisosteric groups was prepared and evaluated for D 1-and D 2- receptor affinity. The 3-methanesulfonamide analogue (18) had a higher affinity for the D 2 receptor than DPDA and was more selective for the D 2 receptor. The 3-formamide derivative (15) also retained significant D 2 affinity. Both of these compounds ...
