The unusually mild and facile basic hydrolysis of N-nitroso-2-(methylamino) acetonitrile

SK Chang, GW Harrington, HS Veale…

Index: Chang,S.K. et al. Journal of Organic Chemistry, 1976 , vol. 41, p. 3752 - 3755

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Citation Number: 14

Abstract

At pH 13 and room temperature, N-nitroso-2-(methylamino) acetonitrile (I) undergoes two unusually fast and successive hydrolytic changes that can be detected quantitatively by differential pulse polarography. The final hydrolysis product is N-nitrososarcosine (III), via the intermediate amide (11). The kinetics and activation parameters of the transformations have been determined. A mechanism has been proposed to account for these rapid ...