Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells

KN Thimmaiah, JK Horton, R Seshadri…

Index: Thimmaiah, Kuntebommanahalli N.; Horton, Julie K.; Seshardi, Ramakrishnan; Israel, Mervyn; Houghton, Janet A.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 18 p. 3358 - 3364

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Citation Number: 33

Abstract

10-(N-piperidinoacety1) phenoxazine were selected as relatively nontoxic chemosensitizers. These modulators, at nontoxic concentrations, potentiated the cytotoxicity of VCR and VLB in GC3/Cl and KBChR-8-5 cells. Further, two compounds lO-(3'-N- morpholinopropyl) phenoxazine, and the butyl derivative, enhanced accumulation of VLB in GC3/C1, KBChR8-5 and highly resistant KB-V1 cells to a level significantly greater than ...