Effect of N α-acyl chain length on the membrane-modifying properties of synthetic analogs of the lipopeptaibol trichogin GA IV

…, F Formaggio, C Peggion, V Monaco…

Index: Toniolo; Crisma; Formaggio; Peggion; Monaco; Goulard; Rebuffat; Bodo Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 4952 - 4958

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Citation Number: 78

Abstract

Trichogin GA IV, an 11-residue lipopeptaibol blocked at the N-terminus by an n-octanoyl group and at the C-terminus by a 1, 2-amino alcohol (l-leucinol), extracted from the fungus Trichoderma longibrachiatum, exhibits remarkable membrane-modifying properties. We have synthesized trichogin GA IV and several [l-Leu-OMe11] analogs carrying at the N- terminus an acyl chain of variable length (C2-C8, C10, C12, C14, C16, C18). A ...