Potential anti-AIDS drugs. 2', 3'-Dideoxycytidine analogs

CH Kim, VE Marquez, S Broder, H Mitsuya…

Index: Kim, Chong-Ho; Marquez, Victor E.; Broder, Samuel; Mitsuya, Hiroaki; Driscoll, John S. Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 862 - 866

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Citation Number: 127

Abstract

5-Substituted 2', 3'-dideoxycytidine analogues have been synthesized and evaluated in vitro for their capabilities to protect T4+ lymphocytes from the cytopathic effects of the HTLV- III/LAV (HIV) virus, the causative agent of acquired immunodeficiency syndrome (AIDS). These analogues were designed to be more lipophilic than 2', 3'-dideoxycytidine (ddC) in order to enhance central nervous system penetration. Earlier reports had shown that ddC ...