Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity

…, RM Baldwin, NS Kula, RJ Baldessarini…

Index: Tamagnan, Gilles; Baldwin, Ronald M.; Kula, Nora S.; Baldessarini, Ross J.; Innis, Robert B. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1113 - 1115

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Citation Number: 12

Abstract

Analogues of the benzazepine dopamine D1 receptor antagonist SCH-23390 incorporating the cyclo-pentadienyltricarbonyl-rhenium (CPTR) moiety were synthesized and evaluated pharmacologically. The CPTR derivatives retained affinity (0.3–2.9 nM) and D1 selectivity of the parent compound, supporting their use as neuropharmacological surrogates for 99mTc- labeled SPECT radiopharmaceuticals.