Tetrahedron Letters

Palladium-catalyzed synthesis of substituted nitroolefins

MY Chang, CH Lin, HY Tai

Index: Chang, Meng-Yang; Lin, Chung-Han; Tai, Hang-Yi Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3194 - 3198

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Citation Number: 3

Abstract

A one-pot protocol toward several substituted nitroolefins 4 and 6 starting with substituted acetones 2 and 5 was described. A facile process was carried out for the triflation of substituted acetones 2 and 5 with triflic anhydride (Tf2O) under the basic condition (Cs2CO3) and then palladium-catalyzed cross-coupling of enol triflates 3 with NaNO2 and BINAP in the presence of phase-transfer reagents (n-Bu4NBr) under the refluxing 1, 2- ...