The syntheses of five metabolites of the antiinflammatory drug etodolac (1, 8-diethyl-1, 3, 4, 9-tetrahydropyrano-[3, 4-b] indole-l-acetic acid) are described, viz. 6-hydroxyetodolac, N- methyletodolac, 4-ureidoetodolac, 8-(1'-hydroxy) etodolac, and 4-oxoetodolac. These syntheses were used to confirm the identities of the metabolites. The metabolites themselves, as well as the previously reported metabolite 7-hydroxyet~ dolac, were tested ...
![1,8-Diethyl-1,3,4,9-tetrahydro-6-hydroxypyrano[3,4-b]indole-1-acetic Acid Methyl Ester Structure](https://image.chemsrc.com/caspic/397/114720-21-7.png)
![1,8-Diethyl-1,3,4,9-tetrahydro-4-oxo-pyrano[3,4-b]indole-1-acetic Acid Methyl Ester Structure](https://image.chemsrc.com/caspic/223/111478-84-3.png)
