A major effort in modern bio-organic chemistry focuses on the design, synthesis and structural characterisation of foldamers:[1] non-natural oligomers that adopt well-defined secondary, tertiary and quaternary structures.[2–5] One ultimate objective of such studies is to recapitulate the functional behaviour of biomacromolecules.[6] Particular emphasis has been placed on inhibitors [7–12] of a-helix-mediated [13] protein–protein interactions [14] ...
