Anti-inflammatory activities of selected synthetic homoisoflavanones

…, HG Kruger, J Bodenstein, P Smith…

Index: Shaikh, Mahidansha M.; Kruger, Hendrik G.; Bodenstein, Johannes; Smith, Peter; Du Toit, Karen Natural Product Research, 2012 , vol. 26, # 16 p. 1473 - 1482

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Citation Number: 6

Abstract

Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti- inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a–4d) were synthesised from the corresponding substituted phenols. 1H-and 13C-NMR data together with high-resolution mass spectroscopy data were employed to ...