Synthesis of a new fluorine-18-labeled bexarotene analogue for PET imaging of retinoid X receptor

M Wang, T Davis, M Gao, QH Zheng

Index: Wang, Min; Davis, Toni; Gao, Mingzhang; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1742 - 1747

Full Text: HTML

Citation Number: 1

Abstract

Abstract The reference standard 2-fluoro-4-(1-(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8- tetrahydronaphthalen-2-yl) vinyl) benzoic acid was synthesized from 2, 5-dimethyl-2, 5- hexanediol and 2-fluoro-4-methylbenzoic acid in 10 steps with 3% overall chemical yield. The precursor 2-nitro-4-(1-(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydronaphthalen-2-yl) vinyl) benzoic acid was synthesized from 2, 5-dimethyl-2, 5-hexanediol and dimethyl-2- ...