Abstract:(-)-Roxaticin hasbeen synthesized frompolyol tetraacetonide5, which wasprepared by a threefold convergent route. Each of the optically pure building blocks (2.3, and 4) was prepared using a Noyori asymmetric hydrogenation. Sequential alkylation of dibromide 3 with cyanohydrin acetonides 2 and 4 followed by stereoselective reductive decyanation gave tetraacetonide 5. The initial approach to roxaticin using a I-methylcyclopropyl ether ...
