The Biginelli Reaction with an Imidazolium–Tagged Recyclable Iron Catalyst: Kinetics, Mechanism, and Antitumoral Activity

…, HCB de Oliveira, AF Gomes, FC Gozzo…

Index: Ramos, Luciana M.; Guido, Bruna C.; Nobrega, Catharine C.; Correa, Jose R.; Silva, Rafael G.; De Oliveira, Heibbe C. B.; Gomes, Alexandre F.; Gozzo, Fabio C.; Neto, Brenno A. D. Chemistry - A European Journal, 2013 , vol. 19, # 13 p. 4156 - 4168

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Citation Number: 48

Abstract

Abstract The present work describes the synthesis, characterization, and application of a new ion-tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive performance. High yields have been achieved when the reaction was carried out in imidazolium-based ionic liquids (BMI⋅ PF 6, BMI⋅ NTf 2, and BMI⋅ BF 4), thus showing that the ionic-liquid effects play a role in the reaction. Moreover, the ion-tagged catalyst ...