A novel class of effective CAIs has been identified, starting from a very weak carbonic anhydrase inhibitor (CAI), sulfamide, whose X-ray crystal structure in the adduct with hCA II has recently been reported. A series of N, N-disubstituted-and N-substituted-sulfamides were prepared from the corresponding amines and N-(tert-butoxycarbonyl)-N-[4-( dimethylazaniumylidene)-1, 4-dihydropyridin-1-ylsulfonyl] azanide or the unstable N-(tert- ...
