e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: 4, 4-disubstituted hexahydro-3H-pyrido [1, 2-c] pyrimidin-3-ones and related …
RJ Chorvat, KA Prodan, GW Adelstein…
Index: Chorvat, Robert J.; Prodan, Kathleen A.; Adelstein, Gilbert W.; Rydzewski, Robert M.; McLauglin, Kathleen T.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1285 - 1291
Individual racemates of the piperidinyl amides 2 were converted to pure racemic diaza bicyclic compounds that were evaluated for antiarrhythmic activity in the Harris dog model and anticholinergic activity in a muscarinic receptor binding assay. Selected compounds were subsequently evaluated for hemodynamic effects in anesthetized dogs where blood pressure depression and negative inotropic activity were assessed. Of this group, 4a (R= ...
![(4R,4aR)-4-[2-(Diisopropylamino)ethyl]-1-methyl-4-phenyl-4,4a,5,6 ,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one Structure](https://image.chemsrc.com/caspic/172/96914-39-5.png)
![1-acetyl-α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide Structure](https://image.chemsrc.com/caspic/364/108438-25-1.png)
![α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-piperidineacetamide Structure](https://image.chemsrc.com/caspic/123/107256-81-5.png)
