Synthesis and pharmacological evaluation of 2-substituted benzo [b] thiophenes as anti-inflammatory and analgesic agents

…, S El-Batran, OMEA El-Salam, SM El-Shenawy

Index: Fakhr, Issa M.I.; Radwan, Mohamed A.A.; El-Batran, Seham; Abd El-Salam, Omar M.E.; El-Shenawy, Siham M. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 4 p. 1718 - 1725

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Citation Number: 57

Abstract

An efficient method for trapping isocyanate 4, generated from the Curtius rearrangement, with ethyl alcohol to afford the carbamate 5 is reported. 5-Nitrobenzo [b] thiophene-2- carboxylic acid 1 is converted to the corresponding hydrazide 2 by the reaction with hydrazine hydrate and then to the azide 3 with nitrous acid, followed by thermal rearrangement, cooling, and trapping in one pot reaction. The carbamate 5 is treated with ...