Abstract A fifteen-step synthesis of methyl cristatate is described. tert-Butyl-[(E)-6-iodo-3- methylhex-2-enyloxy)] diphenylsilane, synthesized from geraniol, was coupled with 2- (diethoxymethyl)-4-lithiofuran and transformed–by acetal hydrolysis, Wittig olefination, and desilylation–into a sesquiterpene furan alcohol. This alcohol was converted into methyl cristatate by sequential condensation with carbonyldiimidazole and the enolate dianion ...
