Further Study of the Synthesis of 4-Hydroxyquinolines from β-Anilinopropionic and Butyric Acids

RC Elderfield, A Maggiolo

Index: Elderfield; Maggiolo Journal of the American Chemical Society, 1949 , vol. 71, p. 1906,1910

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Citation Number: 13

Abstract

In an earlier communication'the results of a preliminary study of the cyclization of p- anilinopropionic acids to 4-keto-1, 2, 3, 4-tetrahydroquino-line derivatives, as first noted by Clemo and Perkin, 2 were reported. In view of the ready availability of such acids by addition of aromatic amines to ethyl acrylate or acrylonitrile this scheme offers attractive possibilities for the synthesis of 4-hydroxy-and 4-chloroquinolines which have recently assumed ...