Synthesis, attempted kinetic resolution and evaluation of [123I]??MK??447 analogues as inflammation radiopharmaceuticals

…, J Shani, SG Pyne, LAP Kane??Maguire

Index: Siu, Anna F. M.; Lambrecht, Richard M.; Shani, Jashovam; Pyne, Stephen G.; Kane-Maguire, Leon A. P. Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 9 p. 711 - 729

Full Text: HTML

Citation Number: 1

Abstract

Abstract The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6- iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123 I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti- inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefulness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The ...