Tetrahedron letters

The Cp 2 TiMe 2-catalyzed intramolecular hydroamination/cyclization of aminoalkynes

I Bytschkov, S Doye

Index: Bytschkov, Igor; Doye, Sven Tetrahedron Letters, 2002 , vol. 43, # 20 p. 3715 - 3718

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Citation Number: 69

Abstract

Cp2TiMe2 has been found to be a competent catalyst for the intramolecular hydroamination/ cyclization of aminoalkynes. In the presence of 5.0 mol% Cp2TiMe2, the hydroamination reactions proceed smoothly at 100–110° C to give five-and six-membered cyclic imines within 4–6 h. After subsequent reduction performed with zinc-modified NaBH3CN at room temperature cyclic amines can be isolated in good yields.