The pyrrole ring is a pivotal structural unit of many pharmacologically active natural products, for example, the lamellarins [1] and prodigiosins.[2] Recently, we have developed a novel silver (I)-promoted oxidative cyclization of homopropargylamines to generate pyrroles,[3] which has been applied to the synthesis of the anti-leishmania active (Æ)- harmicine and the antitumor active (Æ)-crispine A.[4] Homopropargylamines are most ...
