Iron-phosphine,-phosphite,-arsine, and-carbene catalysts for the coupling of primary and secondary alkyl halides with aryl Grignard reagents

RB Bedford, M Betham, DW Bruce…

Index: Bedford, Robin B.; Bruce, Duncan W.; Frost, Robert M.; Hird, Michael Chemical Communications, 2005 , # 33 p. 4161 - 4163

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Citation Number: 205

Abstract

Simple catalysts formed in situ from iron chloride and a wide range of monodentate and bidentate phosphines and arsines have been screened in the coupling of alkyl halides bearing β-hydrogens with aryl Grignard reagents. The best of these show excellent activity, as do catalysts formed in situ with monodentate trialkyl and triaryl phosphite ligands. N- heterocyclic carbene-based precatalysts, either preformed or made in situ, also show ...