Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1, 2] thiazolo [5, 4-d] pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin …

ME Theoclitou, B Aquila, MH Block…

Index: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6734 - 6750

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Citation Number: 22

Abstract

... Journal of Medicinal Chemistry. ... 4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4- methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for ...

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4...

[Theoclitou, Maria-Elena; Aquila, Brian; Block, Michael H.; Brassil, Patrick J.; Castriotta, Lillian; Code, Erin; Collins, Michael P.; Davies, Audrey M.; Deegan, Tracy; Ezhuthachan, Jayachandran; Filla, Sandra; Freed, Ellen; Hu, Haiqing; Huszar, Dennis; Jayaraman, Muthusamy; Lawson, Deborah; Lewis, Paula M; Nadella, Murali V. P.; Oza, Vibha; Padmanilayam, Maniyan; Pontz, Timothy; Ronco, Lucienne; Russell, Daniel; Whitston, David; Zheng, Xiaolan Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6734 - 6750]

Cycloaddition reactions of nitrile sulfides with acetylenic ...

[Journal of Organic Chemistry, , vol. 43, p. 3736 - 3742]