Abstract: The known nocardicins AG have been synthesized, several for the first time, having geometric and stereoisomeric purities of a high order. The syntheses proceed through the central intermediacy of tert-butyl (-)-3-aminocardicinate (14), which has been prepared in a biogenetically patterned, modified Mitsunobu cyclodehydration reaction of a protected L-se- ryl-D-(p-hydroxypheny1) glycine dipeptide 12. An overall 54% yield from the precursor ...
![(2R)-4-Bromo-2-[[(tert-butoxy)carbonyl]amino]butanoic acid tert-butyl ester Structure](https://image.chemsrc.com/caspic/175/123004-74-0.png)
