Tetrahedron letters

Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

…, RR Calvo, LD Davis, KF Erhard, LB Hall, WF Huffman…

Index: Miller, William H.; Ku, Thomas W.; Ali, Fadia E.; Bondinell, William E.; Calvo, Raul R.; Davis, Larry D.; Erhard, Karl F.; Hall, Leon B.; Huffman, William F.; Keenan, Richard M.; Kwon, Chet; Newlander, Kenneth A.; Ross, Stephen T.; Samanen, James M.; Takata, Dennis T.; Yuan, Chuan-Kui Tetrahedron Letters, 1995 , vol. 36, # 52 p. 9433 - 9436

Full Text: HTML

Citation Number: 39

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... An enantiospecific synthesis of SB 214857, a potent, nonpeplide fibrinogen receptor antagonist, is reported. The synthetic route employs as a key step an intramolecular aryl fluoride displacement to form the sevenmembered ring of the 1,4-benzodiazepine system.