The emergence of multi-drug-resistant bacteria has led to an increased demand for new types of antibiotics. 1 The biosynthetic pathway for bacterial cell wall (peptidoglycan) formation represents an attractive target for inhibitor design since many clinically useful antibiotics (such as penicillin and vancomycin) inhibit enzymes of the later stages of this pathway. 2 A set of ligases (MurC-F) is responsible for the synthesis of the UDP-MurNAc- ...
