Highly Efficient Narasaka–Heck Cyclizations Mediated by P (3, 5??(CF3) 2C6H3) 3: Facile Access to N??Heterobicyclic Scaffolds

A Faulkner, JF Bower

Index: Faulkner, Adele; Bower, John F. Angewandte Chemie - International Edition, 2012 , vol. 51, # 7 p. 1675 - 1679

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Citation Number: 39

Abstract

In recent years, the drive for more potent and selective drugs has seen medicinal chemistry move away from “flat” compounds and become increasingly interested in evaluating chiral “3D” drug candidates.[1] The complexities associated with accessing such molecules require the development of more efficient and versatile entries to chiral scaffolds. In this regard, and given the importance of nitrogen,[2] new methods for the efficient and ...