Synthesis of 2??methyl??2??[[(7??methyl??7H??benzo [c] carbazol??10??yl)[14C] methyl [amino]??1, 3??propanediol mesylate—a potential antitumor agent

JA Hill, JF Eaddy

Index: Hill; Eaddy Journal of Labelled Compounds and Radiopharmaceuticals, 1994 , vol. 34, # 8 p. 697 - 706

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Abstract

Abstract 2-Methyl-2-[[(7-methyl-7H-benzo [c] carbazol-10-yl) methyl] amino]-1, 3-propanediol (1, 7U85) was synthesized as the mesylate salt in the [14 C]-labelled form with specific activity 48.4 mCi/mmol suitable for metabolism and tissue distribution studies in animals The synthetic sequence involved the regiospecific synthesis of a bromobenzo [c] carbazole by a modified Fischer indole synthesis, formylation by a Bouveault reaction, and reductive ...