Synlett

Direct copper (I)-catalyzed cycloaddition of organic azides with TMS-protected alkynes

F Cuevas, AI Oliva, MA Pericàs

Index: Cuevas, Felix; Oliva, Ana I.; Pericas, Miquel A. Synlett, 2010 , # 12 p. 1873 - 1877

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Citation Number: 8

Abstract

Abstract A methodology for the direct use of trimethylsilyl-protected alkynes in the copper (I)- mediated alkyne-azide cycloaddition reaction without the need of a previous deprotection step is reported. This methodology is selective for the trimethylsilyl in front of other silicon- based C (sp)-H protecting groups.

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