In order to find new antiasthematic and antithrombotic agents, various [[1-aryl (or benzyl)-1- (benzenesulfonamido) methyl] phenyl] alkanoic acids derivatives were synthesized. Evaluation of these compounds for thromboxane A 2 (TXA 2) antagonistic activities indicated that 4-[4-[(4-chlorobenzenesulfonamido) phenylmethyl] phenyl] butyric acid (6h), 4-[4-[1-(4- chlorobenzenesulfonamido)-2-phenylethyl] butyric acid (6y) and many other compounds ...
