e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis and biological evaluation of substituted 1, 2, 3-benzotriazines and pyrido [3, 2-d]-1, 2, 3-triazines as inhibitors of vascular endothelial growth factor receptor- …
Abstract A novel series of substituted 1, 2, 3-benzotriazines and pyrido [3, 2-d]-1, 2, 3- triazines were synthesized. The abilities of these compounds to inhibit the VEGFR-2 kinase activity and the proliferation of human microvascular endothelial cells (MVECs) were determined. 6-Methoxy-4-substituted-1, 2, 3-benzotriazines and 4-substituted-6-chloro- pyrido [3, 2-d]-1, 2, 3-triazines have the abilities of inhibiting the VEGFR-2 kinase activity, ...
