e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Catalysis by an ionic liquid: efficient conjugate addition of thiols to electron deficient alkenes catalyzed by molten tetrabutylammonium bromide under solvent-free …
The experimental procedure for the reaction is very simple: A mixture of alkene and thiol was added to molten tetrabutylammonium bromide (15 mol%) at 100–105°C and was stirred at that temperature for 1–2 h as required to complete the reaction. The reaction mixture was extracted with ether and the crude product was purified by column chromatography to furnish the pure adduct. The tetrabutylammonium bromide remaining in the reaction flask was washed ...
