Synthesis of 6??dimethylamino??9??[3′??(O??methyl)(2S)??[UL??14C]??tyrosinylamino)??3′??deoxy?螃漫?D??ribofuranosyl] purine

AP Mehrotra, MD Ryan, D Gani

Index: Mehrotra, Amit P.; Ryan, Martin D.; Gani, David Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 6 p. 623 - 634

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Citation Number: 2

Abstract

Abstract In order to investigate and further refine the mechanism of the unique cleavage activity of the 18 amino acid 2A region of the foot-and-mouth-disease virus (FMDV), the synthesis of 14 C-labelled puromycin is required. Puromycin is an inhibitor of protein synthesis and is an analogue of the terminal aminoacyl-adenosine portion of aminoacyl- tRNA. A short and expedient four step synthesis of 6-dimethylamino-9-[3′-([[O-methyl)(2S ...