Identification of novel short chain 4-substituted indoles as potent α v β 3 antagonist using structure-based drug design

P Raboisson, RL DesJarlais, R Reed, J Lattanze…

Index: Raboisson, Pierre; DesJarlais, Renee L.; Reed, Rolanda; Lattanze, Jennifer; Chaikin, Margery; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 334 - 343

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Citation Number: 24

Abstract

The vitronectin receptor αvβ3 has been identified as a promising potential target for the treatment of osteoporosis, diabetic retinopathy and cancer. We have recently reported 5- substituted indoles 3-[5-[2-(5, 6, 7, 8-tetrahydro [1, 8] naphthyridin-2-yl) ethoxy] indol-1-yl]-3- (3-pyridyl) propionic acid 3 and 3-[5-[2-(5, 6, 7, 8-tetrahydro [1, 8] naphthyridin-2-yl) ethoxy] indol-1-yl]-3-(3, 4-methylenedioxyphenyl) propionic acid 4, as an original series of potent ...