Dehydro amino acids (ΔXaa) are found in many naturally occurring peptide antibiotics of bacterial origin as well as in some proteins. 1., , and They have also been used very extensively as rigid scaffolds in structural studies of peptides. 2 In this paper, we report the synthesis of a novel building block based on a pyrrole amino acid (Paa), 5-(aminomethyl)pyrrole-2-carboxylic acid (1), its application in peptidomimetic studies as a conformationally constrained surrogate of the ...
