New derivatives of arylpiperazine 9 were designed from ML 10302, a potent 5-HT4 receptor agonist in the gastrointestinal system. Compounds were synthesized by condensation of a number of available arylpiperazines or heteroarylpiperazines with 2-bromoethyl 4-amino-5- chloro-2-methoxybenzoate. They were evaluated in binding assays on the recently cloned human 5-HT4 (e) isoform stably expressed in C6 glial cells with [3H] GR 113808 as the ...
