e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Preparation of 1, 5??disubstituted 4??sulfonylpyrazoles, β??cyano?螃漫?sulfonylenamines and 5??substituted 4??sulfonylisoxazoles from β??keto?螃漫?sulfonylenamines
Abstract Reaction of β-keto-β-sulfonylenamines 1a, b with N-substituted hydrazines gave 1, 5-disubstituted 4-sulfonylpyrazoles 2a-h in moderate yields, which were ring-opened on treatment with n-butyllithium to afford β-cyano-β-sulfonylenamines (3a, b, df). 5-Substitued 4- sulfonylisoxazoles 6a-d were also prepared from 1a-d and hydroxylamine.
