Hydroxylation of steroid compounds by Gelasinospora retispora

M Koshimura, T Utsukihara, A Hara, S Mizobuchi…

Index: Koshimura, Masahiro; Utsukihara, Takamitsu; Hara, Asako; Mizobuchi, Syuhei; Horiuchi, C. Akira; Kuniyoshi, Masayuki Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 67, # 1-2 p. 72 - 77

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Citation Number: 11

Abstract

Biotransformation of androst-4-ene-3, 17-dione (1), 3β-hydroxypregnan-5-en-20-one (pregnenolone, 2), 3β-hydroxyandrost-5-en-17-one (DHEA, 3) and estradiol (4) was investigated with fungus of Gelasinospora retispora. Biotransformation of 1 gave 11α- hydroxyandrost-4-ene-3, 17-dione (5) in good yield. In the case of compound 2, three compounds, DHEA (3), 3β, 17β-dihydroxyandrost-5-ene (6) and 3β, 15β-dihydroxyandrost ...